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CBD Can Help People with Depression

CBD Can Help People with Depression

As per the American Psychiatric Association, depression affects an approximate one out of fifteen grown-ups each year and one of every six people at some time in their life. For any people who suffers from depression or who has a friend or family member who has depression symptoms, millions of people will agree that this issue is very debilitating amongst the most crippling conditions anyone can face. Fortunately, every year, more people who are diagnosed with any form of depression are finding that CBD or cannabidiol can be a natural choice of option for relieving from this disorder and its side effects. Studies show that CBD interacts with the endocannabinoid system, which is a collection of cell receptors in our brain to regulate essential human functions such as sleep, appetite, mood, pain, and pleasure and other things. So, how do CBD interact with the human body and brain to mitigate the side effects of depression? The intent of this article is to explore the answer to this question, based on scientific research recently conducted in the medical community. But first, let’s have a better understanding of this disorder and then we will know what is CBD and its effects on depression.

What is Depression?

Depression is a sort of mental health disorder related with critical morbidity and mortality, being a major risk factor for suicide, substance abuse, poor outcomes of medical conditions, and impaired functionality. It is described by flattening of mood, loss of emotional expression, and retardation of thought and movements. People who suffered from depression generally have a depressed and discouraged mind-set, loss of enthusiasm in activities they were usually interested in, sleep disorder or insomnia, loss of energy, and reduced ability to think or focus.

The American Psychiatric Association’s Diagnostic Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) categorizes depression into following major depressive disorder like persistent depressive disorder, premenstrual dysphoric disorder, disruptive mood dysregulation disorder, and depressive disorder. However, all these classes of depression are described by the presence of a sad or irritable mood with associated difficulty in thinking, concentrating, and carrying out normal physical tasks, limiting people’s daily functioning.

While human neurochemistry plays a vital role, it is commonly debated that depression is caused by a chemical imbalance in the brain. Rather, Psychology Today argues, “regarding depression as ‘just’ a chemical imbalance wildly misconstrues the disorder.” Scientists agree that levels of neurotransmitters (i.e. chemicals in our brains) are reduced during depression, but this reduction is a symptom of depression rather than a cause.

Between of 2009 and 2012, roughly 7.6% of Americans aged 12 or more were diagnosed with depression and it was more common among females and persons aged 40 and 59. In 2015, about 16.1 million adults aged 18 and over had a minimum of one depressive episode in the previous year.


What are the side effects of Traditional medication for Depression? Traditional treatments for depression are antidepressants, selective serotonin reuptake inhibitor (SSRI), antipsychotic drugs etc. These drugs work by altering the balance of certain chemicals in your brain. And, like all medicines, this change can cause a wide variety of side effects like jitteriness, weird dreams, dry mouth, and diarrhoea and long term decreased sexual desire. "Side effects from antidepressants depend on the class of medication you are using, but in most cases when we talk about side effects, we are talking about SSRIs," says Madhukar Trivedi, MD, a psychiatry professor and director of the Depression Centre at the University of Texas Southwestern Medical Centre in Dallas
Not everyone has the same side effects but some Common Side Effects of Antidepressant medications are:

Nausea
Increased appetite and weight gain
Loss of sexual desire and other sexual problems, such as erectile dysfunction and decreased orgasm
Fatigue and drowsiness
Insomnia
Dry mouth
Blurred vision
Constipation
Dizziness
Agitation
Irritability
Anxiety

What is CBD?
The cannabis plant contains more than 100 different chemical compounds known as cannabinoids, which interact with the body's endocannabinoid system. Cannabidiol or CBD is the most famous among them for having hundreds of medical benefits.
So, Cannabidiol—CBD—is a cannabis compound that has remarkable medical and recreational benefits, but does not make people feel “High”. It can actually prevent the psychoactivity of THC. Cannabidiol is one of at least 113 active cannabinoids identified in cannabis. It is a major phytocannabinoid, accounting for up to 40% of the plants extract. The fact is that CBD-infused cannabis strains are non-psychoactive or less psychoactive than THC-dominant strains. It’s made CBD products a good option for patients looking for relief from inflammation, pain, anxiety, psychosis, seizures, spasms, and other conditions without disconcerting feelings of lethargy or dysphoria. It is 100% natural and free from side effects.

CBD vs. THC
Of every distinctive cannabinoid found in the cannabis plant, the two best known are CBD and THC, or tetrahydrocannabinol but most times, people interchange CBD for tetrahydrocannabinol (THC). The primary difference between THC and CBD is that CBD won't make you high. THC is psychoactive and responsible for the mind-altering effect of cannabis. As long as your CBD products are free from THC, you can reap their potential benefits without going full Pineapple Express.

CBD And Depression
Cannabidiol or CBD is one of the 100+ natural compounds found in all cannabis plants. At the Hebrew University in Jerusalem, Dr. Lumir Hanus along with American researcher Dr. William Devane discovered the endocannabinoid system in human brain which is remarkably responsive to cannabis especially cannabinoids and cannabidiols. Our endocannabinoids are the molecules that act as chemical messengers in the “endocannabinoid system,” the parts of our nervous system containing cannabinoid cell receptors which respond to cannabinoids and tell the body to do certain things.

Unlike THC, the cannabinoid responsible for causing marijuana’s “high effect,” CBD has a smoothing, more indirect interaction with these cell receptors in our brain. Alongside this, CBD has the unique ability to interact directly with other cell receptors, including serotonin and dopamine receptors. Thus, In the time of this interaction, CBD stimulates our brain activity and one by product of this process is the release of serotonin and dopamine throughout the body. Serotonin and dopamine are two hormones are effective on relieving stress and work as natural Antidepressant.

The role of CBD in depression treatment is tied closely to serotonin and dopamine. Now these hormones are the chemicals in our brain that responsible for the impact on both our emotions as well as our motor skills. Serotonin works as our own internal mood stabilizer, and it is very important for healthy sleeping, eating, and digestive habits. Low levels of serotonin and dopamine can lead to depression, and CBD can counter this effect. CBD stimulates our receptors to act more effectively and, therefore, produce more serotonin and dopamine.
Additionally, CBD interacts with the hippocampus in our brain, which partially controls our emotions, when an individual is depressed, the hippocampus become smaller. CBD treatment for depression can result in neurogenesis stimulation, which means more neurons are created by the brain and protects the hippocampus from becoming smaller.

Two recent studies showed benefits of CBD with symptoms of depression. In one study, conducted in 2011 while studying the modulation of the serotonin system through endocannabinoid signalling, researchers found “ample evidence that endocannabinoids are important regulators of stress responses.” Thus, it can be assumed that, during depression, plant cannabinoids such as CBD have the ability to regulate one’s response to stressful situations.

Additionally, Jose Alexandre Crippa and his colleagues at the University of San Paulo in Brazil and King’s College in London found that, at high concentrations, CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect.

A 2011 study at University of British Columbia stated that, “In the last few years, there have been several advances in the determination of the role of the endocannabinoid system in the ethology of depression and the functional actions of antidepressant drugs. Specifically, a deficiency in endocannabinoid signalling is sufficient to produce a "depressive-like" phenotype at the preclinical level…and capable of inducing symptoms of depression in humans at a clinical level. Moreover, facilitation of endocannabinoid signalling is sufficient to produce all of the behavioural and biochemical effects of conventional antidepressant treatments.”
A joint study conducted at Universidad de Cantabria (Spain) and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)(Spain) in 2016 concluded that, “our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia.”

Another 2016 study at Geha Mental Health Center, Petah Tiqva, Israel stated, “These findings extend the limited knowledge on the antidepressant effect of CBD, now shown for the first time in a genetic animal model of depression. These results suggest that CBD is beneficial for the treatment of clinical depression and other states with prominent anhedonia.”
There are many testimonials, reviews and independent studies that give concrete evidence that CBD is a new hope for people suffering with depression.


Many patients go through a frequent problem of shortage of sleep as a side effect of depression. For the relaxing and calming properties of CBD, its effect on sleep is very beneficial. CBD can increase our average sleep time by controlling the sleep-wake cycle. By taking in balanced dose CBD has no sedative side effect and keeps you alert during the day.

Is CBD Addictive?
As per a recent report published by the World Health Organization (WHO), CBD isn't addictive and it has no potential for abuse or dependence. This is fundamentally in light of the fact that CBD does not contain any addictive substances. It also prevents addiction by countering THC and some cannabinoids which are capable of being addictive.


Some Final Tips
Discuss about the proper dose of CBD with your doctor, especially if you are taking other medications for depression. Though CBD typically has no adverse side effects, it’s best to play it safe and keep an open line of communication with your doctor.
Make sure that the CBD products you using come from hemp plants or not from THC dominant strains
Start with the smallest dosages and slowly gear up if more is needed. Everyone reacts CBD differently and there are no exact doses for all. In Treating depression by CBD everyone need is different, so you need to find yours.

Final Words
CBD is natural and it has been shown to have immense health benefits in treating conditions such as anxiety, depression, mood disorders, and inflammatory diseases. CBD can help significantly improve depressive symptoms and people’s quality of life. However, it should be noted that CBD does not cure depression 100% but it can lead to a better quality of life for the patient. We hope you found this article both informative and helpful. Depression makes the life really miserable. It is a difficult thing to treat sometimes and people are often desperate just about anything to curb that feeling. But before you go and try anything too drastic please give a chance to CBD and you too could be one of the many thousands of people whose life CBD has helped to improve just like a miracle.

Keywords: CBD (cannabidiol), Brain/Brain Health, Depression, THC, Full Spectrum, Organic, Non GMO.

References

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors.
Authored by: Zanelati TV1, Biojone C, Moreira FA, Guimarães FS, Joca SR.
https://www.ncbi.nlm.nih.gov/pubmed/20002102
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
Authored by: Wen Jiang, Yun Zhang, Lan Xiao, Jamie Van Cleemput, Shao-Ping Ji, Guang Bai, and Xia Zhang.



Cannabis, Cannabinoids, and Sleep: a Review of the Literature.
Authored by: Babson KA1, Sottile J2, Morabito D3.
https://www.ncbi.nlm.nih.gov/pubmed/28349316


Martin-Santos, R., Crippa, J. A., Batalla, A., Bhattacharyya, S., Atakan, Z., Borgwardt, S., ... & Zuardi, A. W. (2012). Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers. Current pharmaceutical design, 18(32), 4966.


de Souza Crippa, J. A., Zuardi, A. W., Garrido, G. E., Wichert-Ana, L., Guarnieri, R., Ferrari, L., ... & McGuire, P. K. (2004). Effects of cannabidiol (CBD) on regional cerebral blood flow. Neuropsychopharmacology, 29(2), 417.


Fusar-Poli, P., Allen, P., Bhattacharyya, S., Crippa, J. A., Mechelli, A., Borgwardt, S., ... & Zuardi, A. W. (2010). Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol. International journal of neuropsychopharmacology, 13(4), 421-432.

Hill, M. N., Patel, S., Carrier, E. J., Rademacher, D. J., Ormerod, B. K., Hillard, C. J., & Gorzalka, B. B. (2005). Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. Neuropsychopharmacology, 30(3), 508-515.

Chagas, M. H. N., Crippa, J. A. S., Zuardi, A. W., Hallak, J. E., Machado-de-Sousa, J. P., Hirotsu, C., ... & Andersen, M. L. (2013). Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. Journal of Psychopharmacology, 27(3), 312-316.


Devinsky, O., Marsh, E., Friedman, D., Thiele, E., Laux, L., Sullivan, J., ... & Wong, M. (2016). Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. The Lancet Neurology, 15(3), 270-278.

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CBD and Post Traumatic Stress Disorder

 

Post-traumatic stress disorder or PSTD, most commonly seen in war veterans nowadays. It includes uncontrolled and unbearable flashback of previous traumatic experiences which ultimately results in scary level of anxiety and pain. Today many recent researches and studies conducted by scientific community shows that Cannabidiols or CBD found on cannabis plant are highly effective in PSTD treatment. CBD are effective at lessening the emotional impact of traumatic events and can help patients experience less anxiety and fear which gives them relief from pain and improve their sleep.

Understanding PTSD
Before talking about PSTD treatment, let’s try to understand the causes and symptoms of PSTD. According to American Psychiatric Association Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can occur in people who have experienced or witnessed a traumatic event such as a natural disaster, a serious accident, a terrorist act, war/combat, rape or other violent personal assault.


Before talking about PSTD treatment, let’s try to understand the causes and symptoms of PSTD. Though PSTD is a common threat to war veterans, it can common people of any ethnicity, nationality, culture, or age. In PSTD diagnosis direct or indirect exposure to an upsetting traumatic event is observed in the first hand. Numerous methods have been used to treat the symptoms of PSTD throughout the past years. psychotherapy and pharmaceutical medication are traditional methods for PSTD treatment. Now a days CBD as a treatment of PSTD is emerging successfully.
Symptoms and Diagnosis of PSTD
The inherent characteristics of any psychiatric disorders makes them hard to diagnose; according to professionals a patient diagnosed with PSTD if he/she experience all of the following symptoms for at least a month.

Re-experiencing past traumatic symptoms: Flashbacks, bad dreams, frightening thoughts or anything that may cause problems in a person’s everyday routine. Words, objects, or situations can trigger re-experiencing symptoms.

Avoidance symptom: Avoiding thoughts, feelings, places, events or objects that reminds a person of a traumatic event can trigger an avoidance symptom. These symptoms cause a person to change his or her personal routine, such as avoiding cars after a car accident.
Over excitement and reactivity symptoms: Reactivity simply refers to reactions such as “lashing out” in relation to irritability and being triggered by seemingly nothing. Arousal symptoms, on the other hand, are constant. This would be referring to symptoms such and difficulties concentrating or insomnia. These symptoms cause stress and anger, and may cause difficulty eating, sleeping, or concentrating. These symptoms are usually related to the anxiety, insomnia and outbursts connected to PTSD.


Cognition and mood symptoms: These symptoms begin or worsen after a traumatic experience, but are not due to any injury sustained in the event. The symptoms include loss of enjoyment, distorted feelings, negative and pessimistic thoughts, and trouble recalling significant features of the event.


Side effects and problems of traditional medication:
Side-effects:
United States Food and Drug Administration (FDA) has approved sertraline (Zoloft) and paroxetine (Paxil), both antidepressants, for use as post-traumatic stress disorder medication. The side effects of these drugs include:
Headache
Nausea
Sleeplessness or drowsiness
Agitation or a jittery feeling
Problems having or enjoying sex


Physicians also prescribes medications like Zoloft and Paxil genre medications. According the US National Institute of Health (NIH) , benzodiazepines are also used to give relaxation and sleep to patients. The side effects of these 3types of drugs include, problems with memory and the risk of drug dependency. Antipsychotics may be prescribed. They are typically given to patients with coexisting conditions, such as schizophrenia. Some side effects of antipsychotics are weight gain and a higher risk of heart disease and diabetes. Additionally, other antidepressants may be used as PTSD drugs. Possible options are fluoxetine (Prozac) and citalopram (Celexa).

In addition to the side effects already listed, the following side effects may occur:
Dry mouth
Increased appetite
Blurred vision
Dizziness
PTSD Drug Addiction, Dependence and Withdrawal illness:


The Journal of the American Academy of Family Physicians warns about the abuse risk of benzodiazepines. When taken chronically, they can be addictive but they are relatively safe when taken in moderation. If you have a history of substance abuse, benzodiazepines should not be used. It is important that you not cease taking your medication as this can cause withdrawal effects and lead to recurrence of the symptoms of your illness.

Medication Overdose:
The New York Times of February 14,2011 carries the disturbing news of an alarming increase in deaths from accidental overdose among our active duty military personnel and our war veterans. The usual scenario is a diagnosis of PTSD unsuccessfully treated with a wide array of psychotropic drugs, which in their aggregate wind up killing the patient-- often at a very young age. Autopsy reveals significant blood levels of prescribed medication reflecting the heavy drug cocktail and no other apparent cause of death.


PTSD are often prescribed a combination of psychotropics that may include--one antidepressant, one antipsychotic, one antianxiety, one sleep, and one pain medicine. Sometimes, the enormous medication burden is worsened even further--either by the simultaneous prescription of more than one drug from a given class or the additional self-medication effected by the sharing of pills among patients. With this wide range of medication comes with their own side effects and often cause overdose eventually results in death.

 

Using CBD for PTSD
There is no ideal drug treatment for PTSD sufferers, clinical or preclinical however, studies suggest that the endocannabinoid system, which plays an essential role in maintaining emotional homeostasis and in regulating memory retrieval, consolidation and most importantly extinction, is a possible and ideal target to treat both the emotional and cognitive characterizations of PTSD. Martin Lee, a researcher of the Multidisciplinary Association of Psychedelic Research, found people with PTSD had uniformly lower levels of an endocannabinoid called anandamide compared to controls. The experience of PTSD appeared to reset their baseline endocannabinoids at a lower level permanently. Endocannabinoids are involved in regulating dozens of biological and psychological functions, so addressing this deficiency through the highly refined chemistry of cannabis, people experiencing the diverse effects of PTSD can find relief. The endocannabinoid system, first discovered in 1992 by Israeli researcher Dr. Ralph Mechoulam, is made up of two main receptors. These receptors, cannabinoid 1 (CB1) and cannabinoid 2 (CB2), were found to be an integral part of all human and animal physiologies, and are only configured to accept cannabinoids, especially tetrahydrocannabinol (THC) and cannabidiol (CBD). These receptors have been found to modulate the release of neurotransmitters and produce a wide range of effects on the central nervous system, including pleasure and the alteration of the memory process. Research suggests that the cannabinoids found in CBD have the ability to work in conjunction with the cannabinoid receptors to block the continuous retrieval of traumatic events and reduce the anxieties associated with it.

Why CBD is so Helpful for PTSD
The cannabis plant contains more than 100 different chemical compounds known as cannabinoids, which interact with the body's endocannabinoid system. Cannabidiol or CBD is the most famous among them for having hundreds of medical benefits.

So, Cannabidiol—CBD—is a cannabis compound that has remarkable medical and recreational benefits, but does not make people feel “High”. It can actually prevent the psychoactivity of THC. Cannabidiol is one of at least 100 active cannabinoids identified in cannabis. It is a major phytocannabinoid, accounting for up to 40% of the plants extract. The fact is that CBD-infused cannabis strains are non-psychoactive or less psychoactive than THC-dominant strains. It’s made CBD products a good option for patients looking for relief from inflammation, pain, anxiety, psychosis, seizures, spasms, and other conditions without disconcerting feelings of lethargy or dysphoria.


In particular, CBD has been shown to be effective for PTSD. CBD and PTSD aren’t always associated together but CBD has shown to help. CBD does not directly stimulate the endocannabinoid system. Instead, it acts by inhibiting the enzymes that break down the endocannabinoids, much like an MAOI works by blocking serotonin destruction. This raises the levels of anandamide and symptoms are relieved.


Furthermore, because CBD does not directly stimulate the CB1 receptor in the brain, it is not intoxicating. It doesn’t get you high; it just brings relief. No impairment. No sleepiness. No effects that may prevent you from working or participating in society.

Recent Studies on CBD’s Effect on Post-Traumatic Stress Disorder:
These studies showed evidence that how effective is CBD in PSTD treatment. These are all available in govt sites.
PTSD patients saw a 75% reduction in PTSD symptoms, as measured by the Clinical Administered Post Traumatic Scale, when they were using cannabis compared to when they were not.
(http://www.ncbi.nlm.nih.gov/pubmed/24830188)

Evidence from human studies indicates that CBD found in cannabis has considerable potential as a treatment for anxiety disorders.
(http://www.ncbi.nlm.nih.gov/pubmed/26341731)

A review of published evidence finds that cannabinoids help PTSD patients manage the condition’s three major symptoms (re-experiencing, avoidance and numbing, hyperarousal) and helps improve sleep in those PTSD patients suffering from insomnia and nightmares.
(http://www.ncbi.nlm.nih.gov/pubmed/26195653)

Repeated CBD administration prevents the long-lasting anxiogenic effects observed after predator exposure probably by facilitating 5HT1A receptors neurotransmission. Our results suggest that CBD has beneficial potential for PTSD treatment and that 5HT1A receptors could be a therapeutic target in this disorder.
(https://www.ncbi.nlm.nih.gov/pubmed/22979992)

case report of a 19-year-old male patient with a spectrum of severe PTSD symptoms, such as intense flashbacks, panic attacks, and self-mutilation, who discovered that some of his major symptoms were dramatically reduced by smoking cannabis resin…This review shows that recent studies provided supporting evidence that PTSD patients may be able to cope with their symptoms by using cannabis products. Cannabis may dampen the strength or emotional impact of traumatic memories through synergistic mechanisms that might make it easier for people with PTSD to rest or sleep and to feel less anxious and less involved with flashback memories. The presence of endocannabinoid signalling systems within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures (amygdala), point to the significance of this system for the regulation of neuroendocrine and behavioural responses to stress. Evidence is increasingly accumulating that cannabinoids might play a role in fear extinction and antidepressive effects.

(https://www.ncbi.nlm.nih.gov/pubmed/22736575)

CBD both acutely inhibited fear expression and enhanced extinction to produce longer lasting reductions in fear. These observations provide further support for the potential translational use of CBD in conditions such as posttraumatic stress disorder and specific phobias.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/)


The main finding from this case study is that CBD oil can be an effective compound to reduce anxiety and insomnia secondary to PTSD. This case study provides clinical data that support the use of cannabidiol oil as a safe treatment for reducing anxiety and improving sleep in a young girl with posttraumatic stress disorder.
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/)


CBD, PTSD & YOU:
Unlike THC, CBD provides the same medical benefits of hemp plants without experiencing a high. The positive effects of CBD can help PTSD patients manage the core symptoms of the condition which include re-experiencing, avoidance, and hyperarousal.

CBD has become an alternative to traditional drug and psychotherapy treatments in recent years and at least 24 states have approved CBD and cannabinoids for treatment of post-traumatic stress disorder. Frequently used for coping purposes by combat veterans, CBD has proven to be a suitable replacement for traditional drugs in treating emotional regulation, stress tolerance, irregular sleeping patterns, nightmares, social anxieties and lessening the effects of triggers.


While there is no cure for PTSD, CBD is a suitable replacement, backed by medical research, for both drug and psychotherapeutic means of controlling and treating symptoms. Traditionally, PTSD is very difficult to treat due to the plethora of symptoms. While most treatment options only focus on treating a few symptoms, CBD has the ability to treat a wide range of symptoms associated with the disorder. It has the ability to reduce anxiety, help with depression, fight insomnia, and reduce or eliminate flashbacks without the risk of possible substance abuse.


Final Words:
So, now we have it, a current look at how CBD and PTSD is becoming mutually beneficial terms instead of unknown ones. It is encouraging that more and more PTSD patients are choosing CBD as a way to at least take the edge off their pain, depression and anxiety while steadily reducing the amount of prescription meds that they have been prescribed. It’s obvious to all of us who use cannabidiol that CBD improves our quality of life as well as helping to heal our nervous system naturally instead of dealing with unwanted side effects of the aforementioned SSRI’s and SNRI’s.
In fact, all 113+ cannabinoids found in Cannabis are proven safe and non-addictive. CBD as no psycho-active properties (no high or euphoria) and is often recommended by health professionals for children for countless ailments and diseases ranging from PSTD, ADD/ADHD to asthma and epilepsy. CBD products are found with increasing frequency to be preferred by patients of all ages over prescription medication and the countless negative side effects that comes with all of them. If the list of side effects from prescription medications seems antithetical to the discoveries from post-modern medical science.


Any way you look at it, the Veterans Administration is and has been for too long complicit in not only obfuscation of the truth about Cannabis, but withholding of proper medical care and general medical malpractice – the extent of which is only now being exposed. The question persists… How far down the rabbit hole do we have to go to determine the true extent of medical malpractice, insurance fraud, and Big Pharma/U.S. Government collusion that has permeated our medical system?


Keywords
PSTD, CBD, Side-effects, Experience



References:
Akirav, I. (2013). Targeting the endocannabinoid system to treat haunting traumatic memories. Frontiers in Behavioral Neuroscience, 7, 124. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776936/.
Betthauser, K., Pilz, J., and Vollmer, L.E. (2015, August). Use and effects of cannabinoids in military veterans with posttraumatic stress disorder. American Journal of Health-System Pharmacy, 72(15), 1279-84.
Blessing E.M., Steenkamp, M.M., Manzanares, J., and Marmar, C.R. (2015, September 4). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neuotherapeutics, Epub ahead of print. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/26341731.
Boden, M.T., Babson, K.A., Vujanovic, A.A., Short, N.A., and Bonn-Miller, M.O. (2013, May-June). Post-traumatic stress disorder and cannabis use characteristics among military veterans with cannabis dependence. The American Journal on Addictions, 22(3), 277-84.
Bonn-Miller, M.O., Babson, K.A., and Vandrey, R. (2014, March 1). Using cannabis to help you sleep: heightened frequency of cannabinoids use among those with PTSD. Drug and Alcohol Dependence, 136, 162-5.
Bonn-Miller, M.O., Vujanovic, A.A., and Drescher, K.D. (2011, September). Cannabis use among military veterans after residential treatment for posttraumatic stress disorder. Psychology of Addictive Behavior, 25(3), 485-91.
Campos, A.C., Ferreira, F.R., and Guimaraes, F.S. (2012, November). Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5Ht1A receptors. Journal of Psychiatric Research, 46(11), 1501-10.
Greer, G.R., Grob, C.S., and Halberstadt, A.L. (2014, January-March). PTSD symptom reports of patients evaluated for the New Mexico Cannabinoids Program. Journal of Psychoactive Drugs, 46(1), 73-7.
Passie, T., Emrich, H.M., Karst, M., Brandt, S.D., and Halpern, J.H. (2012, July-August). Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence. Drug Testing and Analysis, 4(7-8), 649-59.
Post-traumatic stress disorder (PTSD). (2014, April 15). Mayo Clinic. Retrieved from http://www.mayoclinic.org/diseases-conditions/post-traumatic-stress-disorder/basics/definition/con-20022540.
Potter, C.M., Vujanovic, A.A., Marshall-Verenz, E.C., Bernstein, A., and Bonn-Miller, M.O. (2011, April). Posttraumatic stress and Cannabis use coping motives: the mediating role of distress tolerance. Journal of Anxiety Disorders, 25(3), 437-43.
Trezza, V., and Campolongo, P. (2013, August 9). The endocannabinoid system as a possible target to treat both the cognitive and emotional features of post-traumatic stress disorder (PTSD). Frontiers in Behavioral Neuroscience, 7, 100.
Walsh, Z., Gonzalez, R., Crosby, K., S Thiessmen, M., Carroll, C., and Bonn-Miller, M.O. (2016, October 12). Medical cannabis and mental health: A guided systematic review. Clinical Psychology Review, 51, 15-29.
What is Post-traumatic Stress Disorder (PTSD)? (n.d.). National Institute of Mental Health. Retrieved from http://www.nimh.nih.gov/health/topics/post-traumatic-stress-disorder-ptsd/index.shtml.
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CBD AND CANCER


Cancer and uncontrolled cell development related disease are responsible for 600000 deaths just in USA in 2017. Cancer, by definition, is any cell found in the human body that has uncontrolled growth in this manner imperiling the host with its spread. With that uncontrolled cell development comes inflammation and, regularly, compression of nearby tissue and organs causing pain….unrelenting and disabling. Traditional treatments for Cancer are chemotherapy and radiation therapy; both of which also can cause irritation and breakdown of solid and healthy tissue alongside the tumorous disease cells. Recent research suggests that Cannabinoids (CBD) in preventing cancer cell growth and reducing the ability of tumor cells to reproduce. Now it’s proved researchers that CBD has the ability to cure Cancer.

What is CBD?
Cannabidiol (CBD) is a product that’s derived from cannabis. It’s a type of cannabinoid, which are the chemicals naturally found in marijuana plants. Even though it comes from marijuana plants, CBD doesn’t create a “high” effect or any form of intoxication.

What you will find in this article is reference to numerous scientific studies that all are visible on governmental site. So let’s check it out how CBD cures various type of Cancer

CBD and Breast Cancer
A standout amongst the most exciting areas of current cannabinoid research field is the investigation of the potential use of CBD as antitumor medications. CBD is the main nontoxic exogenous operator that can essentially reduce Id-1 expression in metastatic breast cancer cells prompting the down-control of tumor aggressiveness [1][2]. The CBD concentrations is powerful at restraining Id-1 expression corresponded with those used to inhabit the proliferative and obtrusive phenotype of breast cancer cells. Of the five cannabinoids tried: cannabidiol, cannabigerol, cannnabichromene; cannabidiol-acid and THC-acid, it was discovered that cannabidiol(CBD) is the most powerful inhibitor of cancer cell development[3]. Taken together, these findings set the bases for a cannabidiol (CBD) treatment for the breast cancer.

CBD and Lung Cancer
Studies demonstrate that Δ9-tetrahydrocannabinol found in CBD decreases tumor development, tumor number, and the amount of lung cavity[4]. CBD prompts ICAM-1, and thereby causing TIMP-1 induction and subsequent decreased cancer cell development in lung[5].


Non-small cell lung cancer(NSCLC) is the main cause 50% death due to lung cancer in the world. Researchers have also proved that the treatment of NSCLC cell lines (A549 and SW-1573) with CB1/CB2-and CB2-particular agonists Win55,212-2 and JWH-015, respectively, altogether weakened the intensity of random malignancy growth in vitro chemotaxis and chemo-invasion in these cells[6]. Scientists also observed critical reduction in focal adhesion complex, which plays a major role in cancer migration. CBD suppresses tumor development and lung metastasis (to almost ∼50%)[7].

CBD and Pancreatic Cancer
Recent studies on pancreatic Cancer showed that CBD increases the apoptosis rate of pancreatic tumor cells by means of a CB2 receptor and de novo synthesized ceramide-dependent up-regulation process of p8 and the endoplasmic reticulum stress– related genes ATF-4 and TRB3. These discoveries added the reason for rethinking CBD as a promising option for treating pancreatic Cancer by the National Cancer Institute[8].

CBD and Prostate Cancer:
Prostate cancer cells basically expands by the high abnormal expression of both CB1 and CB2 receptors, and CBD resulting decrease in cancer cell sustainability, expanded apoptosis rate, and lessened abnormal expression in these receptors expression and also decreases prostate-specific antigen excretion[9].

CBD and leukemia and lymphoma
Various studies on human leukemia and lymphoma cells show that after stimulated by CBD, CB1 and CB2 receptors serve our the immune system quite well work as a potential target finder for apoptosis to begin in malignancy affected cell line. Our CB2 receptors work pretty well after treated by cannabinoids like THC and CBD as an active anti-cancer agent but it works best without psychotropic effects. So in this case CBD is ideal for particularly target and kill leukemia cells. CBD also increases the rate of healthy blood cell production in our bone marrow system.


CBD-treated malignancies and tumors displayed an increased number of apoptotic cells with a decreased expression of proangiogenic factors like VEGF a potential tumor growth factor for lymphoma. These outcomes indicates CBD as a helpful approach for the treatment of skin tumors[10][11][12].


CBD in Cancer Treatment – Summary
Many scientific research and studies in Cancer already proved that CBD is highly effective in treating other rare types of cancer like Cervical Cancer [13], Hepatocellular carcinoma [14], skin and throat cancer. So the effectiveness of CBD as a powerful anti-cancer agent can be summarize as bellow

Activating a powerful cancer cell damage mechanism called apoptosis.
Preventing cancer affected cells from dividing and spreading into healthy tissues
#Preventing new blood vessels from turning in tumors.

Accelerating the cell's inside 'waste disposal mechanism' by triggering a process called autophagy. which increases the apoptosis in cancer affected cells.



Few Revolutionary Medical Research and Studies on CBD and Cancer
Cannabis has been the subject of various cancer research studies over the last 20 years. Here is some honorable mentions emphasizing CBD in cancer treatment.


Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. Nasser MW; et al; PLoS One. 2011;6(9):e23901. doi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7; http://www.ncbi.nlm.nih.gov/pubmed/21915267.

Cannabinoids: a new hope for breast cancer therapy?
Caffarel MM et al; Cancer Treat Rev.: 2012 Nov; 38(7):911-8. doi: 10.1016/j.ctrv.2012.06.005. Epub 2012 Jul 7; http://www.ncbi.nlm.nih.gov/pubmed/22776349.

“Cannabinoids Induce Apoptosis of Pancreatic Tumour Cells via Endoplasmic Reticulum Stress–Related Genes” (Cancer Research, 2006)

“Cannabis-based medicine reduces multiple pathological processes in A?PP/PS1 mice” (Journal of Alzheimer’s Disease, 2015)

“Inhibition of skin tumour growth and angiogenis in vivo by action of cannabinoid receptors” (Journal of Clinical Investigation, 2003)

The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications;Juan A. Ramos and Fernando J. Bianco; Indian J Urol. 2012 Jan-Mar; 28(1): 9–14;.doi:10.4103/0970-1591.94942;  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?report=classic
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.
Jia W et al; Mol Cancer Res.; 2006 Aug;4(8):549-62; http://www.ncbi.nlm.nih.gov/pubmed/16908594
Cannabinoids - a new weapon against cancer? BY Pokrywka M1, Góralska J1, Solnica B1.
Closing Thoughts
CBD can help you on the off chance that you are a cancer patient who does not say "we have done whatever we can do" to heart, but always keep the spirit and believe fighting this deadly disease. As mentioned above, numerous scientific studies and researches prove that CBD can be an ideal options for cancer patients. With safe, high quality and natural CBD products we are here to provide you a safe and standard cancer free living in. Visit us today at (Your Website Link)



Keywords: Cannabidiol, CBD, Full Spectrum, Organic, Non GMO, Cell Growth, Uncontrolled.




References
[1] Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. Nasser MW; et al; PLoS One. 2011;6(9):e23901. doi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7; http://www.ncbi.nlm.nih.gov/pubmed/21915267.

[2] Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells; McAllister SDet al; Mol Cancer Ther. 2007 Nov;6(11):2921-7; http://www.ncbi.nlm.nih.gov/pubmed/18025276.

[3] Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation; Caffarel MM et al;
Cancer Res;
2006 Jul 1;66(13):6615-21; http://www.ncbi.nlm.nih.gov/pubmed/16818634

[4] Cannabinoids: a new hope for breast cancer therapy?
Caffarel MM et al; Cancer Treat Rev.: 2012 Nov; 38(7):911-8. doi: 10.1016/j.ctrv.2012.06.005. Epub 2012 Jul 7; http://www.ncbi.nlm.nih.gov/pubmed/22776349

[5] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.Ramer R et al; FASEB J.; 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23; http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract



[6] Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis; Preet A, et al; Cancer Prev Res (Phila). 2011 Jan;4(1):65-75. doi: 10.1158/1940-6207.CAPR-10-0181. Epub 2010 Nov 19; http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

[7] Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo; A Preetet al; Oncogene; (2008) 27, 339–346; doi:10.1038/sj.onc.1210641; published online 9 July 2007;  http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html

[8] https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq#section/all

[9] The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications;Juan A. Ramos and Fernando J. Bianco; Indian J Urol. 2012 Jan-Mar; 28(1): 9–14;.doi:10.4103/0970-1591.94942;  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?report=classic

[10] Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
McKallip RJ et al; Blood. 2002 Jul 15;100(2):627-34.; http://www.ncbi.nlm.nih.gov/pubmed/12091357

[11] Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.
Jia W et al; Mol Cancer Res.; 2006 Aug;4(8):549-62; http://www.ncbi.nlm.nih.gov/pubmed/16908594.

[12] Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
Casanova ML et al: J Clin Invest. 2003 Jan;111(1):43-50; http://www.ncbi.nlm.nih.gov/pubmed/12511587

[13] Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1; Ramer Ret al; Biochem Pharmacol; 2010 Apr 1;79(7):955-66. doi: 10.1016/j.bcp.2009.11.007. Epub 2009 Nov 13; http://www.ncbi.nlm.nih.gov/pubmed/19914218

[14] Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Vara D et al.