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CBD AND CANCER


Cancer and uncontrolled cell development related disease are responsible for 600000 deaths just in USA in 2017. Cancer, by definition, is any cell found in the human body that has uncontrolled growth in this manner imperiling the host with its spread. With that uncontrolled cell development comes inflammation and, regularly, compression of nearby tissue and organs causing pain….unrelenting and disabling. Traditional treatments for Cancer are chemotherapy and radiation therapy; both of which also can cause irritation and breakdown of solid and healthy tissue alongside the tumorous disease cells. Recent research suggests that Cannabinoids (CBD) in preventing cancer cell growth and reducing the ability of tumor cells to reproduce. Now it’s proved researchers that CBD has the ability to cure Cancer.

What is CBD?
Cannabidiol (CBD) is a product that’s derived from cannabis. It’s a type of cannabinoid, which are the chemicals naturally found in marijuana plants. Even though it comes from marijuana plants, CBD doesn’t create a “high” effect or any form of intoxication.

What you will find in this article is reference to numerous scientific studies that all are visible on governmental site. So let’s check it out how CBD cures various type of Cancer

CBD and Breast Cancer
A standout amongst the most exciting areas of current cannabinoid research field is the investigation of the potential use of CBD as antitumor medications. CBD is the main nontoxic exogenous operator that can essentially reduce Id-1 expression in metastatic breast cancer cells prompting the down-control of tumor aggressiveness [1][2]. The CBD concentrations is powerful at restraining Id-1 expression corresponded with those used to inhabit the proliferative and obtrusive phenotype of breast cancer cells. Of the five cannabinoids tried: cannabidiol, cannabigerol, cannnabichromene; cannabidiol-acid and THC-acid, it was discovered that cannabidiol(CBD) is the most powerful inhibitor of cancer cell development[3]. Taken together, these findings set the bases for a cannabidiol (CBD) treatment for the breast cancer.

CBD and Lung Cancer
Studies demonstrate that Δ9-tetrahydrocannabinol found in CBD decreases tumor development, tumor number, and the amount of lung cavity[4]. CBD prompts ICAM-1, and thereby causing TIMP-1 induction and subsequent decreased cancer cell development in lung[5].


Non-small cell lung cancer(NSCLC) is the main cause 50% death due to lung cancer in the world. Researchers have also proved that the treatment of NSCLC cell lines (A549 and SW-1573) with CB1/CB2-and CB2-particular agonists Win55,212-2 and JWH-015, respectively, altogether weakened the intensity of random malignancy growth in vitro chemotaxis and chemo-invasion in these cells[6]. Scientists also observed critical reduction in focal adhesion complex, which plays a major role in cancer migration. CBD suppresses tumor development and lung metastasis (to almost ∼50%)[7].

CBD and Pancreatic Cancer
Recent studies on pancreatic Cancer showed that CBD increases the apoptosis rate of pancreatic tumor cells by means of a CB2 receptor and de novo synthesized ceramide-dependent up-regulation process of p8 and the endoplasmic reticulum stress– related genes ATF-4 and TRB3. These discoveries added the reason for rethinking CBD as a promising option for treating pancreatic Cancer by the National Cancer Institute[8].

CBD and Prostate Cancer:
Prostate cancer cells basically expands by the high abnormal expression of both CB1 and CB2 receptors, and CBD resulting decrease in cancer cell sustainability, expanded apoptosis rate, and lessened abnormal expression in these receptors expression and also decreases prostate-specific antigen excretion[9].

CBD and leukemia and lymphoma
Various studies on human leukemia and lymphoma cells show that after stimulated by CBD, CB1 and CB2 receptors serve our the immune system quite well work as a potential target finder for apoptosis to begin in malignancy affected cell line. Our CB2 receptors work pretty well after treated by cannabinoids like THC and CBD as an active anti-cancer agent but it works best without psychotropic effects. So in this case CBD is ideal for particularly target and kill leukemia cells. CBD also increases the rate of healthy blood cell production in our bone marrow system.


CBD-treated malignancies and tumors displayed an increased number of apoptotic cells with a decreased expression of proangiogenic factors like VEGF a potential tumor growth factor for lymphoma. These outcomes indicates CBD as a helpful approach for the treatment of skin tumors[10][11][12].


CBD in Cancer Treatment – Summary
Many scientific research and studies in Cancer already proved that CBD is highly effective in treating other rare types of cancer like Cervical Cancer [13], Hepatocellular carcinoma [14], skin and throat cancer. So the effectiveness of CBD as a powerful anti-cancer agent can be summarize as bellow

Activating a powerful cancer cell damage mechanism called apoptosis.
Preventing cancer affected cells from dividing and spreading into healthy tissues
#Preventing new blood vessels from turning in tumors.

Accelerating the cell's inside 'waste disposal mechanism' by triggering a process called autophagy. which increases the apoptosis in cancer affected cells.



Few Revolutionary Medical Research and Studies on CBD and Cancer
Cannabis has been the subject of various cancer research studies over the last 20 years. Here is some honorable mentions emphasizing CBD in cancer treatment.


Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. Nasser MW; et al; PLoS One. 2011;6(9):e23901. doi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7; http://www.ncbi.nlm.nih.gov/pubmed/21915267.

Cannabinoids: a new hope for breast cancer therapy?
Caffarel MM et al; Cancer Treat Rev.: 2012 Nov; 38(7):911-8. doi: 10.1016/j.ctrv.2012.06.005. Epub 2012 Jul 7; http://www.ncbi.nlm.nih.gov/pubmed/22776349.

“Cannabinoids Induce Apoptosis of Pancreatic Tumour Cells via Endoplasmic Reticulum Stress–Related Genes” (Cancer Research, 2006)

“Cannabis-based medicine reduces multiple pathological processes in A?PP/PS1 mice” (Journal of Alzheimer’s Disease, 2015)

“Inhibition of skin tumour growth and angiogenis in vivo by action of cannabinoid receptors” (Journal of Clinical Investigation, 2003)

The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications;Juan A. Ramos and Fernando J. Bianco; Indian J Urol. 2012 Jan-Mar; 28(1): 9–14;.doi:10.4103/0970-1591.94942;  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?report=classic
Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.
Jia W et al; Mol Cancer Res.; 2006 Aug;4(8):549-62; http://www.ncbi.nlm.nih.gov/pubmed/16908594
Cannabinoids - a new weapon against cancer? BY Pokrywka M1, Góralska J1, Solnica B1.
Closing Thoughts
CBD can help you on the off chance that you are a cancer patient who does not say "we have done whatever we can do" to heart, but always keep the spirit and believe fighting this deadly disease. As mentioned above, numerous scientific studies and researches prove that CBD can be an ideal options for cancer patients. With safe, high quality and natural CBD products we are here to provide you a safe and standard cancer free living in. Visit us today at (Your Website Link)



Keywords: Cannabidiol, CBD, Full Spectrum, Organic, Non GMO, Cell Growth, Uncontrolled.




References
[1] Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion. Nasser MW; et al; PLoS One. 2011;6(9):e23901. doi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7; http://www.ncbi.nlm.nih.gov/pubmed/21915267.

[2] Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells; McAllister SDet al; Mol Cancer Ther. 2007 Nov;6(11):2921-7; http://www.ncbi.nlm.nih.gov/pubmed/18025276.

[3] Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation; Caffarel MM et al;
Cancer Res;
2006 Jul 1;66(13):6615-21; http://www.ncbi.nlm.nih.gov/pubmed/16818634

[4] Cannabinoids: a new hope for breast cancer therapy?
Caffarel MM et al; Cancer Treat Rev.: 2012 Nov; 38(7):911-8. doi: 10.1016/j.ctrv.2012.06.005. Epub 2012 Jul 7; http://www.ncbi.nlm.nih.gov/pubmed/22776349

[5] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.Ramer R et al; FASEB J.; 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23; http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract



[6] Cannabinoid receptors, CB1 and CB2, as novel targets for inhibition of non-small cell lung cancer growth and metastasis; Preet A, et al; Cancer Prev Res (Phila). 2011 Jan;4(1):65-75. doi: 10.1158/1940-6207.CAPR-10-0181. Epub 2010 Nov 19; http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

[7] Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo; A Preetet al; Oncogene; (2008) 27, 339–346; doi:10.1038/sj.onc.1210641; published online 9 July 2007;  http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html

[8] https://www.cancer.gov/about-cancer/treatment/cam/hp/cannabis-pdq#section/all

[9] The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications;Juan A. Ramos and Fernando J. Bianco; Indian J Urol. 2012 Jan-Mar; 28(1): 9–14;.doi:10.4103/0970-1591.94942;  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?report=classic

[10] Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease.
McKallip RJ et al; Blood. 2002 Jul 15;100(2):627-34.; http://www.ncbi.nlm.nih.gov/pubmed/12091357

[11] Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria.
Jia W et al; Mol Cancer Res.; 2006 Aug;4(8):549-62; http://www.ncbi.nlm.nih.gov/pubmed/16908594.

[12] Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
Casanova ML et al: J Clin Invest. 2003 Jan;111(1):43-50; http://www.ncbi.nlm.nih.gov/pubmed/12511587

[13] Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1; Ramer Ret al; Biochem Pharmacol; 2010 Apr 1;79(7):955-66. doi: 10.1016/j.bcp.2009.11.007. Epub 2009 Nov 13; http://www.ncbi.nlm.nih.gov/pubmed/19914218

[14] Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy. Vara D et al.




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